Nebumetone in binary solvent: solubility analysis

Abstract

The solubility prediction of nabumetone was studied in different solvent system (hexane- ethyl acetate- ethanol- water). The theories such as ideal, Hildebrand-Scatchard and extended Hildebrand solubility approaches were used for finalizing the solubility behavior of nabumetone. Entropy of fusion expression was used to calculate the ideal solubility. The experimental mole fraction solubility deviated from the ideal mole fraction solubility, indicating the self association of solute or solvent or both in solution. The extended Hildebrand equation was used to reproduce solubilities of nabumetone in selected solvent blend. The solubilities of nabumetone were back calculated with an interaction energy term ‘W’ and rational activity coefficient term ‘(log10 2)/A’. These parameters were regressed against a polynomial of δ1, solubility parameter of solvent blend. Solubility parameter of the nabumetone δ2 was determined and found to be ˜ 20 MPa 1/2