Lemon juice; Efficient and eco-friendly natural catalyst for one pot multicomponent synthesis

Abstract

Citric acid present in lemon juice is used as natural acid catalyst for one pot synthesis of various heterocyclic compounds with formation of products in high yield.Among other fruit extract lemon juice is given top priority for one pot multicomponent synthesis due to feature such as non toxic inexpensive, easily available, biodegradable.The catalyst is many organic reaction reflectors the importance and High expectation in kofield of research.Citric acid plays an important role as biocatalyst in the synthesis of key intermediate for the pharmaceutical and chemical industry. A multicomponent reaction (MCR) is a convergent reaction in which three or more starting material react to form a single product , where essentially all or modt of the aton contribute to the newly formed product.In recent years multicomponent reaction had gain much importance in organic synthesis, since they produced the desired product in single operation without isolating the intermediate.The advantages of MCRs are one pot reactions consume very less amount of solvent or no solvent, superior atom economy, generally takes less time compared to divergent reaction,lower cost, simple procedure and environment friendly. KEYWORDS One pot synthesis; lemon juice; biocatalyst; citric acid.