Green synthesis of dihydropyrimidinone using solvent free grinding method

Abstract

A facile protocol for one pot (Multicomponent) synthesis of Pyrimidinone derivative through Beginelli reaction by completely different inexperienced ways like heating without catalyst, grinding within the presence of catalyst Cerric nitrate (CAN) and ammonium chloride (NH4Cl) has been performed. The reaction has been continuing smoothly below solvent free condition on grinding of mixture of various organic compound i.e Benzaldehyde, ethyl acetoacetate and urea during a mortar. Dihydropyrimidinone area unit the vital bioactive heterocyclic compounds, this has established an attention in revising the new drug entities based mostly upon the dihydropyrimidinone activity. Its intercalary importance in Pharmaceutical and medicative field thanks to its broad biological activities. The analysis is performed and compared for synthesized product exploitation completely different inexperienced ways. It's been additionally screened for antibacterial drug activity. On comparison, it's been found that grinding technique is a smaller amount time intense as compared to heating and was command while not generating any pollution in quicker time interval, safe to analyst and easy to handle. The good thing about this new protocol lies in avoiding the organic solvent, varied substrate, use low-cost or cheap catalyst that all contributes to safer chemistry.