Transdermal gel embedded with medicated solid lipid nanoparticles (sln’s)”

Abstract

Rheumatoid/Osteoarthritis is one of the most common causes for lacking behind in the health sector. Medication in the form of tablets is already available in the market but has disadvantages like: when taken orally as it reacts with the stomach acidic pH causing heartburn and belching and patients with existing liver disease suffer more with NSAIDs used for RA. Introduction of the Transdermal drug delivery system over the last few decades have changed the perspective of the prescriber and also the patient’s compliance is well taken care of. Here, in this study the transdermal drug delivery system in accordance with Nanoparticles with Solid Lipid as carrier with surfactant/polymer and drug used in Arthritis. INDOMETHACIN is clearly observed and studied for further evaluation. Studies also show that drugs like Indomethacin and Estradiol, when studied in rat models, were able to be enhanced when incorporated into Nanoparticles. Method by which the entire study was performed was with the help of Probe Sonicator that works on the principle of high intensity ultrasound waves to break bigger particle agglomerates into smaller ones. Suitable methods are HIGH PRESSURE HOMOGENISER and SOLVENT EVAPORATION METHOD. With High pressure homogeniser, problems such as low efficiency of product process were found out, but with Solvent Evaporation method, the sonication process went easily. Evaluation parameters of nanoparticles formulation are: 1) Particle Size Determination by Zetasizer as an instrument 2) Gel formulations are pH determination, Spreading coefficient, Viscosity, Visual appearance & Clarity.