Teratogenic and hepatoprotective activity of edible lime using the zebrafish model

Abstract

Many local Vaidya have been giving Edible lime for the treatment of jaundice and other liver diseases. Also, it is infamously consumed along with tobacco for ages. The purpose of this investigation was to determine lethal concentration 10 (LC10) and study the hepatoprotective activity of Edible lime on the zebrafish model. LC10 value of Edible lime was calculated by using probit analysis, and it was found to be 95.49 mg/L. Liver toxicity was induced in zebrafish larvae by using paracetamol. Liver atrophy, yolk sac retention, increase in optical density of liver, increased in the level of AST and ALT revealed paracetamol-induced liver toxicity in zebrafish larvae. The Edible lime showed a significant increase in liver size, and decrease in yolk sac retention, reduced liver degeneration, reduced AST and ALT level. The present study revealed the hepatoprotective activity of Edible lime.