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Effects of Liver Impairment on the Pharmacokinetics of Brivanib, a Dual Inhibitor of Fibroblast Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Tyrosine Kinases

Syed, Shariq (StemScientific, 2000)

Background: Many patients with hepatocellular carcinoma (HCC) have liver impairment as a result of tumor burden and cirrhosis. Brivanib, which is administered orally as the prodrug brivanib alaninate, is a selective, dual ...
Multiple Dose Pharmacokinetics of Caffeine Administered in Chewing Gum to Normal Healthy Volunteers

Syed, Shariq (BIOPHARMACEUTICS & DRUG DISPOSITION, 2005)

The purpose of this study was to examine the pharmacokinetics of three doses of caffeine administered as Stay Alert1 chewing gum in a multiple dose regimen. Methods: A double-blind, parallel randomized, four-treatment ...
Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse

Syed, Shariq (THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007)

Recently, extensive behavioral research has been conducted on the benztropine (BZT) analogs with the goal of developing successful therapeutics for cocaine abuse. The present study was conducted to characterize the ...
Population Pharmacokinetics, Brain Distribution, and Pharmacodynamics of 2nd Generation Dopamine Transporter Selective Benztropine Analogs Developed as Potential Substitute Therapeutics for Treatment of Cocaine Abuse

Syed, Shariq (JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 97, NO. 5, MAY 2008, 2008-05)

A second generation of N-substituted 3a-[bis(40-fluorophenyl)methoxy]- tropanes (GA 1–69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to ...
Petrography and geochemistry of magnesite and talc deposits of Jhiroli, Kumaun Lesser Himalaya

Joshi, Prabha (Magmatism, Tectonism And Mineralization: Macmillan Publishers India Ltd, 2009)

The Veitsch type magnesite mineralization in association with talc from Jhiroli is confined within the stromatolitic dolomite of Deoban Formation. The dolomite represents many microlithotypes and characterized by nodules ...
Role of fluids in the formation of talc deposits of Rema area, Kumaun Lesser Himalaya

Joshi, Prabha (Springer, 2009-02)

Talc deposits of Rema area in the Kumaun Inner Lesser Himalaya are hosted within high magnesium carbonates of the Proterozoic Deoban Formation. These deposits occur as irregular patches or pockets mainly within magnesite ...
Learning from the Past Intrusion Attacks: Digital Evidence Collection to Make e-Commerce Systems More Secure

Lokhande, P. S. (Conference ICL2009, 2009-09)

Use of computers, data communication and data storage devices has become so ubiquitous that most of the crimes or civil disputes have involvement in some way. There will be a large demand for computer forensics in the ...
Investigation on the characteristic properties of high performance SCC with mineral admixtures

Patil, Dada S. (Indian Concrete Journal, 2009-09)

In this experimental work, a mix design for self-compacting concrete has been carried out using Nan-Su method. Flow properties such as passing ability, filling ability, and segregation resistance were evaluated by varing ...
Website evaluation of select industries: an evaluation

Ansari, Shaheen N. (CESER Publications, 2010)

Technology has expanded the range and ease of information access at the expense of personal contact. The implications for libraries are substantial: a need to more clearly identify groups of users and their different ...
Genetic issues of some of the non metallic minerals in lesser Himalaya

Joshi, Prabha (Iranian Journal of Earth Sciences, 2010)

A brief account of the representative and workable industrial minerals namely magnesite, talc and barite in Lesser Himalaya, is presented here emphasizing their genesis. Deposits of magnesite and talc are found associated ...
Lack of Effect of Brivanib on the Pharmacokinetics of Midazolam, a CYP3A4 Substrate, Administered Intravenously and Orally in Healthy Participants

Syed, Shariq (Journal of Clinical Phramacology, Online 9 June 2011, 2011)

Brivanib alaninate is the orally available prodrug of brivanib, a dual inhibitor of fibroblast growth factor and vascular endothelial growth factor signaling pathways that is under therapeutic investigation for various ...
Lack of food eVect on single-dose pharmacokinetics of brivanib, and safety and eYcacy following multiple doses in subjects with advanced or metastatic solid tumors

Syed, Shariq (Cancer Chemotherapy and Pharmacology, 2011)

Purpose Brivanib alaninate, an orally available prodrug of brivanib, is currently under evaluation for the treatment of several malignancies. This study aimed to (1) investigate eVects of a high-fat meal on single-dose ...
Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy

Syed, Shariq (British Journal of Cancer, 2011)

BACKGROUND: The objectives of this phase I study were to determine the safety, pharmacokinetics (PK), pharmacodynamics and efficacy of brivanib combined with full-dose cetuximab in patients with advanced gastrointestinal ...
Phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors

Syed, Shariq (Annals of Oncology, 2011)

Background: This study was designed to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of brivanib in patients with advanced/metastatic solid tumors. Patients and methods: Ninety patients enrolled ...
Use of statistical methods in construction industry

Parkar, Fauwaz (International Conference on Civil, Structural and Environmental Engineering: ICSEE, 2011-02-18)

While manufacturing industry has generally been capable to apply new concepts successfully, construction industry still appears failing to apply them. Although these two industries differ significantly from each other, ...
Evaluation of curculigo orchioides mucilage as suspending agent

Gaikar, Nilesh (International Journal of PharmTech Research, 2011-04)

Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices compared to imported synthetic products. The present study was undertaken to evaluate ...
Lack of Effect of Brivanib on the Pharmacokinetics of Midazolam, a CYP3A4 Substrate, Administered Intravenously and Orally in Healthy Participants

Syed, Shariq (Sage Pubicaiton, 2011-06)

Brivanib alaninate is the orally available prodrug of brivanib, a dual inhibitor of fibroblast growth factor and vascular endothelial growth factor signaling pathways that is under therapeutic investigation for various ...
Luver as protagonist

Dalvi, Smita (Domus India, 2011-11)

Addressing the negotiation of the interior with the climate of the city. Bimal Patel and his multi-disciplinary team design the hardware for the skins of three building.
Architecture of new mosques in Kerala: appropriated aesthetics in the aftermath of urbanisaiton and globalisation

Dalvi, Smita (International Conference on Islamic Art & Architecture (ICIAA), 2011-11)

In recent times, the architectural features of the old mosques in Kerala, India are in the process of being replaced. traditional mosques were built in timber and like other religious structures in Kerala emerged from ...
Intermittent reservoir daily-inflow prediction using lumped and distributed data multi-linear regression models

Magar, Rajendra (Indian Academy of Science, 2011-12)

In this study, multi-linear regression (MLR) approach is used to construct intermittent reservoir daily inflow forecasting system. To illustrate the applicability and effect of using lumped and distributed input data in ...

Now showing items 1-20 of 172

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