• In vitro and in vivo screening of anti-inflammatory activity of methalonic and aqueous extracts of anogeissus latifolia leaves 

  Shaikh, Saba (PHF009); Badruddeen; Khan, Mohammad Irfan; Ajaz Ahmad, (PHF002) (Innovare Publications, 2022)

  Objective: To evaluate and compare anti-oxidant and anti-inflammatory activity of methanolic and aqueous extract of Anogeissus latifolia leaves Methods: The in vitro antioxidant activity was investigated using nitric ...
• Nebumetone in binary solvent: solubility analysis 

  Kharwade, Meena (International Research Journal Of Pharmacy, 2017)

  The solubility prediction of nabumetone was studied in different solvent system (hexane- ethyl acetate- ethanol- water). The theories such as ideal, Hildebrand-Scatchard and extended Hildebrand solubility approaches were ...
• Formulation and evaluation of transfersomal cream of Acriflavin 

  Gaikwad, Madhuri (International Research Journal Of Pharmacy, 2016-09)

  A burn can be major medical problems or life threatening emergencies admitted to any hospital. Conventional topical burn formulations are required to be applied 3 to 4 times a day and previous application is needed to be ...
• Comparative in vitro antidiabetic and antioxidant activity of various extracts of Ficus specie 

  Shaikh, Abusufyan (Pharmacogn J., 2018)

  ABSTRACT Introduction: Ficus religiosa, Ficus benghalensis and Ficus glomerata are plants from Ficus species used traditionally for the treatment of various ailments. This study aimed to investigate in vitro antidiabetic ...
• A review on polymer drug conjugate - what, why and how? 

  Patil, Jayshree P. (International ournal of Pharmaceutical Sciences and Research, 2015-11-01)

  ABSTRACT: It is well known that polymeric prodrug or polymer-drug conjugate is an effective and fast growing technique for improved use of drugs for therapeutic applications. Polymer conjugated drugs generally exhibit ...
• Formulation and development of mouth dissolving tablets of isolated molecules and evaluation for anti-hyperglycemic activity 

  Farhana, Nikhat (Research Journal of Pharmacy and Technology, 2014-03)

  Fast disintegrating drug delivery system offers a solution for those patients who are having difficulty in swallowing oral dosage forms. The present paper deals with formulation and evaluation of fast dissolving tablets ...
• Comparative study of anti-inflammatory activity of aqueous and methanolic extracts of hibiscus cannabinus leaf (Malvaceae) 

  Shaikh, Saba (International Journal of Pharmacy and Pharmaceutical Sciences, 2016-04)

  Objective: The present study was undertaken to investigate and compare the anti-inflammatory activity of an aqueous and methanolic extract of Hibiscus cannabinus (Malvaceae) using carrageenan-induced rat paw ...
• Evaluation of curculigo orchioides mucilage as suspending agent 

  Gaikar, Nilesh (International Journal of PharmTech Research, 2011-04)

  Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices compared to imported synthetic products. The present study was undertaken to evaluate ...
• Evaluation of Aegle marmelos fruit mucilage for binding properties 

  Gaikar, Nilesh (International Journal of Pharmaceutical Sciences & Research, 2012-04)

  Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices. Natural gums and mucilages are widely explored as pharmaceutical excipients. The present ...
• Application of Box–Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity 

  Mirza, Salman Baig (International Journal of Biological Macromolecules, 2015-12-29)

  The aim ofthe present study was to develop and optimize levofloxacin loaded solid lipid nanoparticles for the treatment of conjunctivitis. Box–Behnken experimental design was applied for optimization of solid lipid ...
• Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse 

  Syed, Shariq (THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007)

  Recently, extensive behavioral research has been conducted on the benztropine (BZT) analogs with the goal of developing successful therapeutics for cocaine abuse. The present study was conducted to characterize the ...
• Population Pharmacokinetics, Brain Distribution, and Pharmacodynamics of 2nd Generation Dopamine Transporter Selective Benztropine Analogs Developed as Potential Substitute Therapeutics for Treatment of Cocaine Abuse 

  Syed, Shariq (JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 97, NO. 5, MAY 2008, 2008-05)

  A second generation of N-substituted 3a-[bis(40-fluorophenyl)methoxy]- tropanes (GA 1–69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to ...
• Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy 

  Syed, Shariq (British Journal of Cancer, 2011)

  BACKGROUND: The objectives of this phase I study were to determine the safety, pharmacokinetics (PK), pharmacodynamics and efficacy of brivanib combined with full-dose cetuximab in patients with advanced gastrointestinal ...
• Phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors 

  Syed, Shariq (Annals of Oncology, 2011)

  Background: This study was designed to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of brivanib in patients with advanced/metastatic solid tumors. Patients and methods: Ninety patients enrolled ...
• Multiple Dose Pharmacokinetics of Caffeine Administered in Chewing Gum to Normal Healthy Volunteers 

  Syed, Shariq (BIOPHARMACEUTICS & DRUG DISPOSITION, 2005)

  The purpose of this study was to examine the pharmacokinetics of three doses of caffeine administered as Stay Alert1 chewing gum in a multiple dose regimen. Methods: A double-blind, parallel randomized, four-treatment ...
• Lack of food eVect on single-dose pharmacokinetics of brivanib, and safety and eYcacy following multiple doses in subjects with advanced or metastatic solid tumors 

  Syed, Shariq (Cancer Chemotherapy and Pharmacology, 2011)

  Purpose Brivanib alaninate, an orally available prodrug of brivanib, is currently under evaluation for the treatment of several malignancies. This study aimed to (1) investigate eVects of a high-fat meal on single-dose ...
• Lack of Effect of Brivanib on the Pharmacokinetics of Midazolam, a CYP3A4 Substrate, Administered Intravenously and Orally in Healthy Participants 

  Syed, Shariq (Journal of Clinical Phramacology, Online 9 June 2011, 2011)

  Brivanib alaninate is the orally available prodrug of brivanib, a dual inhibitor of fibroblast growth factor and vascular endothelial growth factor signaling pathways that is under therapeutic investigation for various ...
• Effects of Liver Impairment on the Pharmacokinetics of Brivanib, a Dual Inhibitor of Fibroblast Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 

  Syed, Shariq (StemScientific, 2000)

  Background: Many patients with hepatocellular carcinoma (HCC) have liver impairment as a result of tumor burden and cirrhosis. Brivanib, which is administered orally as the prodrug brivanib alaninate, is a selective, dual ...
• SYNTHESIS AND ANXIOLYTIC ACTIVITY OF 2-METHYL-3-AMINO-4- QUINAZOLINONE ACETAMIDE DERIVATIVES 

  Patil, Jayshree P. (Coden HLEEAI, 2014)

  Medicinal Chemistry plays a vital role in the eradication of fatal diseases in human being. Quinazolin-4-one is versatile lead molecule. The synthesis of its derivatives has been the focus of great interest for the ...
• Review on Advances in the Synthesis and Bioactivity of Quinazolinone Derivative 

  Patil, Jayshree P. (International Journal for Pharmaceutical Research Scholars (IJPRS), 2014)

  Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. Many of the literature synthetic methods for elaboration of this simple ...

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