ABSTRACT Introduction: Ficus religiosa, Ficus benghalensis and Ficus glomerata are plants from Ficus species used traditionally for the treatment of various ailments. This study aimed to investigate in vitro antidiabetic ...

Background: Many patients with hepatocellular carcinoma (HCC) have liver impairment as a result of tumor burden and cirrhosis. Brivanib, which is administered orally as the prodrug brivanib alaninate, is a selective, dual ...

The coconut plant Cocos nucifera (family Arecaceae) is considered as an important fruit crop in tropical countries. It is commonly available plant with wide variety of applications in food, drinks, fibres, building materials ...

Fast disintegrating drug delivery system offers a solution for those patients who are having difficulty in swallowing oral dosage forms. The present paper deals with formulation and evaluation of fast dissolving tablets ...

Diabetes mellitus is the most common endocrine disorder, affecting 16 million individuals in the US and 200 million worldwide....

Brivanib alaninate is the orally available prodrug of brivanib, a dual inhibitor of fibroblast growth factor and vascular endothelial growth factor signaling pathways that is under therapeutic investigation for various ...

Purpose Brivanib alaninate, an orally available prodrug of brivanib, is currently under evaluation for the treatment of several malignancies. This study aimed to (1) investigate eVects of a high-fat meal on single-dose ...

Hypertension is a chronic disease which required lifelong therapy. But most of antihypertensive drugs available today, showed extensive first-pass metabolism and low oral bioavailability which can be overcome by preparing ...

BACKGROUND: The objectives of this phase I study were to determine the safety, pharmacokinetics (PK), pharmacodynamics and efficacy of brivanib combined with full-dose cetuximab in patients with advanced gastrointestinal ...

A second generation of N-substituted 3a-[bis(40-fluorophenyl)methoxy]- tropanes (GA 1–69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to ...