Abstract:
The project was merely focusing on to carry out the disconnection approach, with existing Tylenol
(acetaminophen) to develop the sustainable protocol, on one-pot synthesis. The extensive literature
survey projected the background data of work done on Tylenol and its derivatives, by adopting
different chemical methods, our study prime focused on to design the sustainable protocol by
applying the one-pot methodology, with N-Acetylation using Mg-acetate which was the first time
approach. It is also observed that the use of a catalytic amount of Mg-acetate in acetic acid is
sufficient enough for smooth running of N-acetylation reactions. The procedure was chemoselective
with respect to phenols, acids and alcohols. Herein we reported a simple, efficient, costeffective
and environmentally benign alternative method for N-acetylation of amines using
catalytic amount of Magnesium acetate in I mole of acetic acid under rotation on magnetic stirrer
for 1hr at 250rpm. The reaction procedure requires no other solvent and it was a rapid process with
good to excellent yields. The synthesized molecular structure was confirmed by FT-IR, NMR, and
Mass spectral data during XRD-analytical diffraction scan, which suggested the complete
agreement on key functionality identification structure of the molecule using powdered
diffractometer preliminary analysis, the data scanned and calculated accurately with 2 coverage
the detection of good reflections was noted and hence we prove, on the basis of spectra the
stereochemistry of functionality was different from existing Tylenol the toxicity study and
biological screening are under process in our laboratory. This project would be the novel method
in the future for development of antipyretic antiviral molecules if it gave positive results for the
activity.
Keywords: Magnetic rotation, amines, acetic acid, Magnesium acetate, N-acetylation, chemoselectivity,
Toxicity, biological screening
