Formulation and evaluation of medicated nano soft jelly

Abstract

Silymarin is the extract of Silybum marianum, or milk thistle, and it is a mixture of flavonolignans (of which silybin is the most prevalent substances) and one flavonoids. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis, because of its antioxidant, anti-inflammatory and anti-fibrotic power. Silymarin also helps with the digestion of fats. Silymarin is associated with poor aqueous solubility and poor bioavailability, which is due to extensive first pass metabolism. The purpose of this study is to develop and characterize medicated Nano jelly of Silymarin for increasing bioavailability and bypass extensive first pass metabolism. The medicated Nano jellies were formulated by heating and congealing method. Batches were prepared using different concentration of gelling agents and almond gum. The prepared batches were evaluated for appearance, viscosity, size less than 240nm, pH (6.54±0.5), drug content (62% to 90%), stability, and syneresis. Analysis was done using UV-Vis Spectrophotometer, FTIR & Zeta sizer. Keywords:- Silymarin, Nanojellies, Gelling Agents, congealing method