Formulation and evaluation of in-situ ophthalmic gel

Abstract

The delivery of drug to eye suffer major challenges like Jess absorption & bioavailability because of drainage of the drug solution from the ocular tissue etc. In this study in-situ gel was developed to overcome this problem. In-situ gel which is considered to be in the form of a solution at room temperature which then gets transformed into a gel when it is inserted in the eye by the effect of the physiological conditions like ionic strength, pH & the temperature. In present study the gelling property due to body temperature was exploited. Various concentration of poloxamer 188 and poloxamer 407 mixture were prepared and evaluated. Its effect on gelling temperature was studied. Gelling at body temperature was observed for a few formulations. Further, effect of ratio of poloxamer 188 and poloxamer 407 was studied on gelling temperature. Evaluation for the viscosity, pH, and clarity was performed for optimum formulation. In situ gel is promising ophthalmic drug delivery dosage form