Abstract:
In this report we are preparing an ointment containing microspheres
formulated with curcuminand Musturdfor the treatment of skin disease known
as psoriasis. Psoriasis is a T-cell mediated auto immune inflammatory skin
disease recognised by skin surface inflammation, anomalous keratinisation
etc.Curcumin is a main yellow bioactive component of turmeric,possess wide
spectrum of biologicalaction.
antiinflammatory,antioxidants,anticarcinogenic,antifungal,antibacterial,antiprot
ozoal activity.However the benefits are by its extremely poor aqueous
solubility,which subsequently limits its bioavailability and therapeutic effect of
curcumin.
The musturd oil can applied directly on to the skin, can also help to fight with
fungal infection also relieve the painful effects of rheumatism and arthritis as
well as help in join a hens and pains.
The aim of present work was to formulate curcumin and mustard microspheres
containing sodium alginate as a microencapsulating polymer were loaded in
salicylic acid cream which is prepared to be applied topically on the skin for
purpose of sustaining effects of the drug.
The drug release from microspheres based cream exhibited a controlled release
pattern.The methodology included the use of sodium algenate containing
curcumin and mustard microspheres were prepared by emulsion solvent
evaporation method,and using DMSO as solvent for penetration enhancer.
The resulting microspheres are characterize by employing scanning electron
microscope (SEM). Further, the microspheres are dispersed in salicylic acid
cream (1 %w/w). The cream is evaluated for appearance,
homogeneity,spreadability, viscosity, ph, and in Vitro drug diffusion study.
Keywords:Microspheres,Drugdelivery,preparation,applications,SEM
