Novel drug delivery system for Psoriasis

Abstract

In this report we are preparing an ointment containing microspheres formulated with curcuminand Musturdfor the treatment of skin disease known as psoriasis. Psoriasis is a T-cell mediated auto immune inflammatory skin disease recognised by skin surface inflammation, anomalous keratinisation etc.Curcumin is a main yellow bioactive component of turmeric,possess wide spectrum of biologicalaction. antiinflammatory,antioxidants,anticarcinogenic,antifungal,antibacterial,antiprot ozoal activity.However the benefits are by its extremely poor aqueous solubility,which subsequently limits its bioavailability and therapeutic effect of curcumin. The musturd oil can applied directly on to the skin, can also help to fight with fungal infection also relieve the painful effects of rheumatism and arthritis as well as help in join a hens and pains. The aim of present work was to formulate curcumin and mustard microspheres containing sodium alginate as a microencapsulating polymer were loaded in salicylic acid cream which is prepared to be applied topically on the skin for purpose of sustaining effects of the drug. The drug release from microspheres based cream exhibited a controlled release pattern.The methodology included the use of sodium algenate containing curcumin and mustard microspheres were prepared by emulsion solvent evaporation method,and using DMSO as solvent for penetration enhancer. The resulting microspheres are characterize by employing scanning electron microscope (SEM). Further, the microspheres are dispersed in salicylic acid cream (1 %w/w). The cream is evaluated for appearance, homogeneity,spreadability, viscosity, ph, and in Vitro drug diffusion study. Keywords:Microspheres,Drugdelivery,preparation,applications,SEM