Novel drug delivery system for Psoriasis

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dc.contributor.author Mukadam, Masarrat
dc.contributor.author Mukadam, Sabiha Rafique (16PH33)
dc.contributor.author Mujawar, Faiza Faiz Ahmed (16PH32)
dc.contributor.author Khan, Wsasim Mohammed (16PH25)
dc.contributor.author Khan, Uzaid Mohammed Aslam (16PH27)
dc.date.accessioned 2021-11-12T04:42:52Z
dc.date.available 2021-11-12T04:42:52Z
dc.date.issued 2020-05
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/3679
dc.description.abstract In this report we are preparing an ointment containing microspheres formulated with curcuminand Musturdfor the treatment of skin disease known as psoriasis. Psoriasis is a T-cell mediated auto immune inflammatory skin disease recognised by skin surface inflammation, anomalous keratinisation etc.Curcumin is a main yellow bioactive component of turmeric,possess wide spectrum of biologicalaction. antiinflammatory,antioxidants,anticarcinogenic,antifungal,antibacterial,antiprot ozoal activity.However the benefits are by its extremely poor aqueous solubility,which subsequently limits its bioavailability and therapeutic effect of curcumin. The musturd oil can applied directly on to the skin, can also help to fight with fungal infection also relieve the painful effects of rheumatism and arthritis as well as help in join a hens and pains. The aim of present work was to formulate curcumin and mustard microspheres containing sodium alginate as a microencapsulating polymer were loaded in salicylic acid cream which is prepared to be applied topically on the skin for purpose of sustaining effects of the drug. The drug release from microspheres based cream exhibited a controlled release pattern.The methodology included the use of sodium algenate containing curcumin and mustard microspheres were prepared by emulsion solvent evaporation method,and using DMSO as solvent for penetration enhancer. The resulting microspheres are characterize by employing scanning electron microscope (SEM). Further, the microspheres are dispersed in salicylic acid cream (1 %w/w). The cream is evaluated for appearance, homogeneity,spreadability, viscosity, ph, and in Vitro drug diffusion study. Keywords:Microspheres,Drugdelivery,preparation,applications,SEM en_US
dc.language.iso en en_US
dc.publisher AIKTC en_US
dc.subject Project Report - SoP en_US
dc.title Novel drug delivery system for Psoriasis en_US
dc.type Project Report en_US


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