Abstract:
Schiff bases have gained importance in medicinal and pharmaceutical fields due to a broad
spectrum of biological activities and have been utilized as synthons in the preparation of a
number of industrial and biologically active compounds. Quinazolines and quinazolinones
are medicinally important nitrogen hetero cyclic compounds. The combination of unique
structural features, extensive functionalization, and very high biological activity found, both
building blocks are tethered together to synthesize new chemical entity (NCE) 3-
(benzylideneamino)-2-methyl-quinazolin-4-one, i.e. schiff base using lemon juice as green
solvent. Utilization of fruit juices as a natural and biocatalyst permits mild and highly
selective transformation and synthesis in a simplistic and environmentally friendly manner.
The present synthesis proceeds via synthesis of Methyl-2- acetamidobenzoate from methyl
anthranilate followed by cyclization to produce 3-amino-2-methyl quinazolin-4-one which
on treament with benzaldehyde produces schiff base.The synthesized product was identified
by its physical properties, melting point, TLC, FTIR and characterized by NMR. It is
screened for antibacterial and antioxidant properties. Compared with traditional methods, this
green method was more convenient and held without generation of pollution in shorter
reaction time, safer to analyst, low cost and simple to run.
Keywords: Schiff base, Quinazolinone, fruit juice, bio catalyst
