Abstract:
Parkinson disease (PD) is the second most common
neurodegenerative disorder, after Alzheimer’s disease. The incidence of
PD increases after the age of 50 and rapidly increases after the age
of 75. PD is characterized by motor and non-motor features. The most
common motor symptoms are tremor, rigidity, akinesia (lack of
movement), bradykinesia (slow movements), hypokinesia (reduced
movement), that occur mainly due to the degeneration of dopaminergic
neurons, involved in the movement coordination and located in the
substantia nigra pars compacta. However, in later stages of the disease, it
affects other brain regions.
Since the available medication of the drugs for the treatment of
Parkinson’s disease have seen to have many extrapyrimidal side effects
and lesser drugs are present of herbal origin. The purpose of this study is to
check and evaluate the efficacy of the phytoconstituent (curcumin) in
treatment of parkinson’s disease using zebrafish as a model organism .
Curcumin, a yellow pigment present in turmeric has been shown to
exhibit numerous activities such as antioxidant, anti-inflammatory,
antimicrobial, hepatoprotective, anticarcinogenic, thrombosuppressive and
cardiovascular as well have potential to show anti Parkinson activity, is
extracted from one of the approved methods and characterized using
thin layer chromatography technique. Curcumin related to
neuroprotection is its anti-oxidant function that can protects substantia
nigra neurons, increases striatal dopamine level , which is necessary for
the treatment of parkinson’s disease.
Keywords: Parkinson’s disease, Zebrafish, Curcumin.
