Abstract:
Citric acid present in lemon juice is used as natural acid catalyst for one pot synthesis of various
heterocyclic compounds with formation of products in high yield.Among other fruit extract
lemon juice is given top priority for one pot multicomponent synthesis due to feature such as
non toxic inexpensive, easily available, biodegradable.The catalyst is many organic reaction
reflectors the importance and High expectation in kofield of research.Citric acid plays an
important role as biocatalyst in the synthesis of key intermediate for the pharmaceutical and
chemical industry.
A multicomponent reaction (MCR) is a convergent reaction in which three or more
starting material react to form a single product , where essentially all or modt of the aton
contribute to the newly formed product.In recent years multicomponent reaction had gain much
importance in organic synthesis, since they produced the desired product in single operation
without isolating the intermediate.The advantages of MCRs are one pot reactions consume very
less amount of solvent or no solvent, superior atom economy, generally takes less time
compared to divergent reaction,lower cost, simple procedure and environment friendly.
KEYWORDS
One pot synthesis; lemon juice; biocatalyst; citric acid.
