Abstract:
Humans have developed many medications for their safety and for improving their
quality of life. Among all the different medications antibiotics are most commonly
prescribed in every disease state. Teratogenic and toxicity studies of different
antibiotics to date have demonstrated significant effects in both animal models and
clinical studies. The purpose of this investigation was to determine lethal
concentration 10 (LC10), hatchability, mortality, and heart rate and study the
teratogenic effect and toxicity of Erythromycin in the zebrafish model. Probit
analysis is used to calculate LC10 value , and it was found to be 44.66 mg/L. In the
case of Erythromycin hatchability decreases with increasing dose, mortality
increases with increasing dose, and heart rate decreases with increasing dose.
However, no effect was observed on the morphological characteristics in developing
embryos of zebrafish larvae. This research can be used in considering the safety of
Erythromycin for their use during pregnancy.
