Abstract:
Many local Vaidya have been giving Edible lime for the
treatment of jaundice and other liver diseases. Also, it is
infamously consumed along with tobacco for ages. The purpose
of this investigation was to determine lethal concentration 10
(LC10) and study the hepatoprotective activity of Edible lime on
the zebrafish model. LC10 value of Edible lime was calculated by
using probit analysis, and it was found to be 95.49 mg/L. Liver
toxicity was induced in zebrafish larvae by using paracetamol.
Liver atrophy, yolk sac retention, increase in optical density of
liver, increased in the level of AST and ALT revealed
paracetamol-induced liver toxicity in zebrafish larvae. The
Edible lime showed a significant increase in liver size, and
decrease in yolk sac retention, reduced liver degeneration,
reduced AST and ALT level. The present study revealed the
hepatoprotective activity of Edible lime.
